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Mesothelioma is a form of cancer which occurs in thin membranes (called the mesothelium) lining the chest, lungs, abdomen and sometimes the heart. Although quite rare, mesothelioma symptoms strike more than 200 people each year in the United States. The majority of mesothelioma cases are directly linked to asbestos exposure. Because of the long latency period of mesothelioma, the average age of patients is between 50 and 70 years. Mesothelioma affects men most due to the high exposure of asbestos in industrial typed jobs. Mesothelioma symptoms include respiratory problems, shortness of breath, continual cough and pneumonia. Other mesothelioma symptoms include weight loss, abdominal problems and swelling. In some mesothelioma patients, the mesothelioma symptoms are quite muted, making it hard for mesothelioma doctors to diagnose. Mesothelioma doctors specialize in the study, research, and treatments of Mesothelioma cancers. Mesothelioma (or the cancer of the mesothelium) is a disease in which cells become abnormal and replicate without control. During Mesothelioma, these cells will invade and damage tissues and organs. Mesothelioma cancer cells can spread throughout the body causing death. Mesothelioma treatments and Mesothelioma clinical trials and tests There are many mesothelioma treatment options available. Treatments include surgery, radiation therapy and chemotherapy and the mesothelioma treatment depends on the patient’s age, general health and stage of the cancer. There has been much mesothelioma research conducted throughout the past two years to find new treatment methods. Click here to read more about mesothelioma treatment techniques. Through mesothelioma research, The National Cancer Institute has sponsored mesothelioma tests and clinical trials that are designed to find new treatment methods. Because of the increase in number of mesothelioma cases in the United States, both governments have increased funding for mesothelioma research. Mesothelioma research and clinical trials have been successful in developing new techniques to fight this cancer and the outlook for more advanced mesothelioma treatments is promising. Surgery is the most common treatment method for malignant mesothelioma. Tissues and linings affected by mesothelioma are removed by the doctor and may include the lung or even diaphragm. A second mesothelioma treatment method is radiation therapy through the use of high energy x-rays that kill the cancer cells. Radiation therapy can be outside or inside the body. A third mesothelioma treatment method is chemotherapy. Through pills or drugs through needles, chemotherapy drugs are used to kill cancer cells. A new mesothelioma treatment method is called intraoperative photodynamic therapy. In this treatment, light and drugs are used to kill cancer cells during surgery for early stages of mesothelioma in the chest. Although there are numerous treatments and drugs for mesothelioma, doctors are losing the battle against this deadly disease. Most mesothelioma treatments involve old techniques combined with different drug cocktails. However, in most cases, these mesothelioma treatments have many side effects including organ damage, nausea, increase in heart failure etc. The rush to find a more effective mesothelioma treatment or even cure is ongoing at numerous clinical labs across the nation. Let's hope that the mesothelioma treatments will one day erradicate mesothelioma cancer and asbestosis. With an abundance of information on the Internet, Mesothelioma Cancer and Asbestos ([http://www.mesothelioma-cancer-and-asbestos.com]) has consolidated the most important issues surrounding Mesothelioma, Mesothelioma doctors and symptoms, Mesothelioma treatment, Mesothelioma research and tests. At [http://www.mesothelioma-cancer-and-asbestos.com], the website contains useful resources on Mesothelioma lawyers and attorneys, as well as causes by asbestos exposure, asbestos removal, asbestos attorneys and lawsuits, and asbestos cancer. Patients stricken by Mesothelioma and their families require support and current information. Mesothelioma Online Resources hopes to educate and give hope to survivors and victims. Mesothelioma is such a harsh disease. Not only does it take years for symptoms to appear, but there are limited treatements and drugs that will prolong the lives of workers stricken with mesothelioma. In many cases, the death rate of mesothelioma is unfortunately very high. However, with increased funding in mesothelioma research through the government and private grants, the outlook for a mesothelioma cure is quite possible. In the meantime, mesothelioma support groups and local discussions provide the ongoing support for mesothelioma patients. Mesothelioma Cancer and Asbestos ([http://www.mesothelioma-cancer-and-asbestos.com])is your source for mesothelioma and asbestos information, treatments, clinical trials, attorneys, support groups and lawyers. About the website: Michael Kenneth is a successful Internet Publisher and has researched and written on many topics for [http://www.mesothelioma-cancer-and-asbestos.com] - your complete source for mesothelioma information, mesothelioma attorneys and lawyers, mesothelioma treatments and research, asbestos exposure and removal, asbestos attorneys and legislation as well as asbestos cancer.

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Mesothelioma PATHOLOGY WRITTEN BY: W. Roy Smythe See Article History Mesothelioma, a tumour that arises from the sheet of cells known as the mesothelium, which lines body cavities and forms the tissue layers referred to as the pleura and the peritoneum. The pleura is located in the chest cavity, either lining the chest wall (parietal pleura) or covering the lung (visceral pleura), and the peritoneum is the corresponding tissue in the abdomen. Roughly 75 percent of mesothelioma cases originate in the chest. Mesothelial cells can also be found in other areas of the body, such as the scrotal sac and the pericardium (the sac surrounding the heart), and in rare cases the tumour may arise primarily in those locations. Some 2,000 to 3,000 cases of mesothelioma are diagnosed annually in the United States and more elsewhere around the world, related in part to asbestos exposure rates. For males born between 1945 and 1950 in western Europe, researchers projected that mesothelioma during the period from 1995 to 2029 would reach rates as high as 1 in 150 because of asbestos exposure in this population. Causes Of Mesothelioma There is an unequivocal association with asbestos exposure in about 80 percent of cases. The latency period between exposure and the development of disease typically ranges from 20 to 50 years, with an average of about 30 years. Other causative agents, such as SV40 (simian virus 40), have been postulated; however, data are inconclusive. Some cases are idiopathic, in which no known cause can be identified. Use of asbestos was strictly regulated in the United States beginning in the latter part of the 20th century, though it is still used in the developing world. Erionite, which is similar to asbestos, is found in the soil in Turkey and is associated with concomitant pockets of high mesothelioma incidence. The biology of asbestos exposure and subsequent development of cancer is not clearly understood, because of the long latency period. However, a chronic inflammatory reaction, causing DNA damage to the mesothelial cells, is likely involved. Unlike lung cancer, the eventual development of mesothelioma is not associated with smoking. asbestos; mesothelioma asbestos; mesothelioma Asbestos chrysotile fibres are responsible for the lung diseases known as asbestosis and mesothelioma. © Terry Davis/Shutterstock.com Diagnosis And Subtypes Of Mesothelioma The diagnosis of mesothelioma usually occurs at advanced stages, because the thin layer of tumour that develops may not be discernible in X-rays, nor may it lead to symptoms. The most common complication leading to an eventual diagnosis is pleural effusion (a collection of fluid around the lung in the pleural space), whereby a person becomes short of breath. Pain is common with more-advanced disease, when the tumour invades the ribs and muscles of the chest wall. The use of computed tomography (CT; computerized axial tomography) is essential to determine the extent of disease and the stage of tumour development. CT scanning is also used to determine whether the patient might be considered a candidate for surgery. Positron emission tomography (PET) is useful to assist in the determination of metastasis (spread) to other areas of the chest or body. Serum biomarkers, such as mesothelin, osteopontin, and megakaryocyte potentiating factor, have shown some promise for the development of blood tests to screen for the disease, as well as for following patients for evidence of recurrence after treatment. There are many subtypes of mesothelioma, based on microscopic pathologic examination. The most common subtype is epithelial mesothelioma, followed by biphasic, or mixed, disease, which has epithelial and sarcomatous (connective tissue) involvement; less common is the solely sarcomatoid subtype. The pathologic diagnosis of mesothelioma, using microscopic techniques, can be difficult and often requires that a battery of immunohistochemistry (IHC) tests be performed on each tumour to determine whether it is mesothelioma or perhaps another type of tumour that has spread to the thoracic or abdominal cavity. IHC uses colorimetric antibodies directed at proteins on the surfaces of cells. A pattern of both positive and negative staining is interpreted by the pathologist. Some of the more common positive-staining antibodies that are used include WT1 (Wilms tumour 1) and mesothelin and cytokeratin 5/6. Commonly used negative-staining epithelial antibodies include CEA (carcinoembryonic antigen), LeuM1, and TTF-1 (thyroid transcription factor 1). Survival Prediction And Treatment Reported survival for patients with mesothelioma has been relatively poor, ranging in most cases from 9 to 18 months with or without treatment. Factors used to predict survival include epithelial subtype, involvement of regional (mediastinal) lymph nodes, and size of the tumour. The ability to completely remove the tumour at surgery and the use of multimodality (surgery, chemotherapy, and radiation therapy) in some combination-therapy approaches can also influence survival. Advances in multimodality therapy have included the use of a class of chemotherapy drugs referred to as folate antimetabolites. The most common drug used in this class is pemetrexed, which is most effective when combined with platinum-based agents, such as cisplatinum. These drugs may be given as definitive treatment to patients that are not surgical candidates, and up to 50 percent of treated individuals may respond with tumour arrest and shrinkage and modestly improved survival. Clinical trials have evaluated the use of these drugs prior to surgery (neoadjuvant therapy). The weight of evidence indicates that surgical removal of the tumour is important for improved survival, but only if surgery is included with other therapies. Care must be taken when determining whether a patient should undergo surgery, since many patients are at advanced age. Removal of the tumour alone from the surfaces on which it is growing (a procedure known as pleurectomy) may be best in early-stage patients. A more aggressive operation, extrapleural pneumonectomy (EPP), may be required in more-advanced cases. EPP involves the removal of tumour, pleura, diaphragm, and pericardium, with reconstruction of the latter two structures. The tumour grows over a very large surface area, and for that reason the risk of local recurrence following surgery is high. Many modalities have been evaluated and are being used for adjuvant (after surgery) treatment, including heated chemotherapy instillation (gradual introduction of liquid drug into cancerous tissue), photodynamic therapy (administration of a drug that becomes active when the cancerous tissue is exposed to a certain form of light), and various forms of radiation therapy. Local control over the administration of therapy can be made more precise by the use of computerized conformal radiation therapy techniques, such as intensity-modulated radiation therapy, in which three-dimensional CT is used to guide the delivery of very precise doses of radiation to the tumour or to parts of the tumour. A number of experimental approaches to treatment capitalizing on the presence of biological or molecular targets have been attempted. Some promising future targets identified in clinical studies have included proteins (e.g., mesothelin) that are commonly found on mesothelioma cells. Growth factors, antiangiogenic drugs, which block the growth of tumour blood vessels, and molecules that stimulate programmed cell death (apoptosis) have also been investigated. W. Roy Smythe

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